BB and Hippocampus
Itinerary - View Abstract: "Abstract View
BLUEBERRY EXTRACT IMPROVES SURVIVAL OF GRAFTED HIPPOCAMPAL FORMATION: BIOLOGICAL MECHANISMS
L.M.Willis1*; C.D.Umphlet1; V.Zaman1; A.Moore1; P.C.Bickford3; A.C.Granholm1,2
1. Dept Neurosciences, 2. Center on Aging, Med. Univ. of South Carolina, Charleston, SC, USA
3. Dept. Neurosurgery, Univ. of South Florida, Tampa, FL, USA
Dietary supplementation with foods high in antioxidants, such as blueberries, has been shown to improve memory and increase neurogenesis in the hippocampus of aged rats. In addition to their potent antioxidant properties, blueberries have been shown to decrease mRNA for the pro-inflammatory cytokine TNF in certain brain regions. Considering that oxidative stress and inflammation can both be detrimental to the survival of grafted neural tissue, the present study focused on biological mechanisms of blueberry extract in terms of improving graft survival in an intraocular grafting paradigm. Graft recipients were given either a control diet or a diet that had been supplemented with 2% blueberry extract one week prior to transplantation and were maintained on the respective diets for the duration of the study. Fetal hippocampal tissue (E18) was transplanted to the anterior eye chamber of young adult (6 mo) and middle-aged (19 mo) recipients. Fetal hippocampal grafts to middle-aged hosts exhibited poor survival, less overall growth, and reduced organization. When middle-aged graft recipients were maintained on a diet with blueberry extract, survival of hippocampal intraocular grafts was greatly improved: size and cellular organization of grafts was comparable to that seen in tissue grafted to young recipients. Preliminary results indicate that blueberries may enhance neo-vascularization and reduce inflammation following the ocular surgery. Thus, our preliminary data indicate that the active ingredients of this nutraceutical may provide various neuroprotective"
BLUEBERRY EXTRACT IMPROVES SURVIVAL OF GRAFTED HIPPOCAMPAL FORMATION: BIOLOGICAL MECHANISMS
L.M.Willis1*; C.D.Umphlet1; V.Zaman1; A.Moore1; P.C.Bickford3; A.C.Granholm1,2
1. Dept Neurosciences, 2. Center on Aging, Med. Univ. of South Carolina, Charleston, SC, USA
3. Dept. Neurosurgery, Univ. of South Florida, Tampa, FL, USA
Dietary supplementation with foods high in antioxidants, such as blueberries, has been shown to improve memory and increase neurogenesis in the hippocampus of aged rats. In addition to their potent antioxidant properties, blueberries have been shown to decrease mRNA for the pro-inflammatory cytokine TNF in certain brain regions. Considering that oxidative stress and inflammation can both be detrimental to the survival of grafted neural tissue, the present study focused on biological mechanisms of blueberry extract in terms of improving graft survival in an intraocular grafting paradigm. Graft recipients were given either a control diet or a diet that had been supplemented with 2% blueberry extract one week prior to transplantation and were maintained on the respective diets for the duration of the study. Fetal hippocampal tissue (E18) was transplanted to the anterior eye chamber of young adult (6 mo) and middle-aged (19 mo) recipients. Fetal hippocampal grafts to middle-aged hosts exhibited poor survival, less overall growth, and reduced organization. When middle-aged graft recipients were maintained on a diet with blueberry extract, survival of hippocampal intraocular grafts was greatly improved: size and cellular organization of grafts was comparable to that seen in tissue grafted to young recipients. Preliminary results indicate that blueberries may enhance neo-vascularization and reduce inflammation following the ocular surgery. Thus, our preliminary data indicate that the active ingredients of this nutraceutical may provide various neuroprotective"
posted by Tim | 1:06 PM
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